Peptides for sleep
Deep sleep, REM and circadian rhythm are among the most common reasons people try peptides. The strongest evidence on this page is not from a peptide marketed for sleep at all.
Ranked by strength of evidence
- S+Tirzepatide
Treats moderate-to-severe obstructive sleep apnea in adults with obesity
Approved for sleep apnea — the only sleep claim here backed by large trials.
Read the evidence → - B
- B
- BDSIP
Improves sleep in people with chronic insomnia
Named for the effect in 1977. Three small studies, 36 patients total, and the best-controlled one was negative.
Read the evidence → - B
- B
The honest read
The peptides marketed specifically for sleep rest largely on self-report and small studies. The one entry on this page with large randomized trials behind it earned that grade for treating sleep apnea — a specific medical condition, diagnosed and treated by a clinician.
Looking at a different goal? Browse all use cases, or get every peptide’s grade on one page.