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The Peptide Evidence Report Card

One glance at all 31 peptides we cover — graded S+ to C on the strength of the human evidence. The proven, the promising, and the overhyped, side by side. No hype, no sales pitch, and never a recommendation.

How the 31 headline grades break down

S+11
Strongest human evidence
S9
Some human evidence
A6
Mostly preclinical
B4
Mostly anecdotal
C1
Unsupported / overstated

Grades are claim-specific — the report card shows each peptide's headline claim and the grade for that claim. Most peptides are graded on several claims, and the same molecule can be S+ for one use and C for another. Every grade traces back to a source-checked brief.

A look inside

One peptide from each tier

S+
CagrilintideMetabolic / weight loss (long-acting amylin analog)

Combined with semaglutide (CagriSema), produces large weight loss in adults with obesity or overweight

S
CJC-1295Growth hormone / recovery (GHRH analog)

Raises growth hormone and IGF-1 (sustained, for the DAC version)

A
5-Amino-1MQMetabolic / fat loss (NNMT inhibitor — a small molecule, not a peptide)

Inhibits NNMT to raise NAD+ and reduce fat storage / obesity (preclinical)

B
DSIPSleep (a 1977 candidate sleep factor, never confirmed)

Improves sleep in people with chronic insomnia

C
AOD-9604Fat loss / metabolic (HGH fragment)

Produces meaningful weight or fat loss in humans

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Evidence grade key

S+
Strongest human evidenceMultiple large human RCTs or strong clinical consensus
S
Some human evidenceHuman studies exist — limited, mixed, or narrow in scope
A
Mostly preclinicalMostly animal / lab data with a plausible mechanism
B
Mostly anecdotalCommunity and anecdotal claims, little or no human data
C
Unsupported / overstatedUnsupported, contradicted, or overstated by the evidence

For educational purposes only. Not medical advice, and never a dosing recommendation or a suggestion to use any peptide. Grades reflect published research at the time of review. Prefer to read the receipts? Browse the full source-checked briefs.