Peptides for libido and sexual function
The melanocortin peptides, including one that made it all the way through FDA approval. This is a use case where a peptide genuinely cleared the bar — and where the gray-market version of that same peptide did not.
Ranked by strength of evidence
- SPT-141 (Bremelanotide)
Increases sexual desire and reduces desire-related distress (HSDD) in premenopausal women
FDA-approved as Vyleesi for this exact indication.
Read the evidence → - SMelanotan II
Triggers erections and increases sexual desire
A well-documented effect — and the reason PT-141 was developed from it.
Read the evidence → - SKisspeptin
Modulates sexual brain processing and increases arousal in men with low sexual desire
A real randomized trial — by intravenous infusion, in an MRI scanner, with brain activity as the primary endpoint.
Read the evidence → - BPT-141 (Bremelanotide)
Improves erectile dysfunction or low libido in men
The approval covers premenopausal women; the male use is less established.
Read the evidence → - BHCG
Raises testosterone in men who are not on testosterone replacement therapy
A prescription drug, used off-label as a testosterone route. The supporting data is a 20-man series with no control group.
Read the evidence → - COxytocin
Improves sexual function, desire, or orgasm
The crossover trial that tested this found placebo did slightly better on every measure.
Read the evidence →
The honest read
PT-141 is one of the clearest wins in the whole catalog: a peptide that ran the trials and got approved for a real indication. That approval covers the prescribed product, Vyleesi, obtained through a prescriber.
Looking at a different goal? Browse all use cases, or get every peptide’s grade on one page.