Peptides for blood sugar and metabolic health

Type 2 diabetes, insulin sensitivity and cardiovascular risk. This is the best-evidenced use case in the entire catalog, because it is where the pharmaceutical industry ran the large trials.

Ranked by strength of evidence

  1. S+
    Semaglutide

    Improves blood-sugar control and lowers cardiovascular risk in type 2 diabetes

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  2. S+
    Tirzepatide

    Improves blood-sugar control in type 2 diabetes

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  3. S+
    Mazdutide

    Improves blood-sugar control in adults with type 2 diabetes

    Approved for diabetes in China. Beat dulaglutide head-to-head; the semaglutide comparison is not yet published.

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  4. S+
    Semaglutide

    Reduces major cardiovascular events in adults with overweight/obesity and established heart disease

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  5. S
    Retatrutide

    Reduces liver fat in people with obesity

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  6. B
    NAD+ (and precursors NMN / NR)

    Improves metabolic health (glucose, lipids, insulin sensitivity) in people

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The honest read

Every top grade on this page belongs to a prescription medicine studied in tens of thousands of people. If metabolic health is the goal, this is the part of the category where the evidence is genuinely overwhelming — and all of it runs through a prescriber.