Peptides for longevity and healthy aging

The anti-aging end of the category, where the marketing is boldest and the human evidence is thinnest. Several of these have genuinely interesting mechanisms; none has shown a lifespan effect in people.

Ranked by strength of evidence

  1. S+
    NAD+ (and precursors NMN / NR)

    Oral NMN / NR raises blood NAD+ levels

    That it raises NAD+ is settled. What that does for you is the next line down.

    Read the evidence →
  2. A
    Epithalon

    Activates telomerase and lengthens telomeres (shown in cultured human cells and animals)

    Read the evidence →
  3. A
    MOTS-c

    Improves insulin sensitivity and reproduces exercise-like metabolic adaptations (preclinical)

    Read the evidence →
  4. B
    NAD+ (and precursors NMN / NR)

    Slows or reverses human aging / extends lifespan

    Read the evidence →
  5. B
    SS-31 (Elamipretide)

    Slows aging, 'repairs mitochondria,' or boosts energy in otherwise healthy adults

    Read the evidence →
  6. B
    Thymosin Alpha-1

    Broadly 'boosts immunity' or supports anti-aging in otherwise healthy people

    Read the evidence →
  7. C
    Epithalon

    Extends human lifespan or reduces mortality

    The claim the category is sold on. Traced back, it rests on a different compound than the one sold as Epitalon.

    Read the evidence →

The honest read

This page is the clearest illustration of why claim-specific grading exists. The same compound can have a well-established mechanism and an unsupported lifespan claim — and the second one is what gets put on the label.

Looking at a different goal? Browse all use cases, or get every peptide’s grade on one page.